Non-steroidal anti-inflammatory

Analgesic, antipyretic and anti-inflammatory

Gelatin Soft Capsules

Ibuprofen works by non-selectively inhibiting cyclooxygenase enzymes. These enzymes produce inflammatory chemicals called prostaglandins (PGs) that trigger pain sensations and cause inflammation throughout the body. NSAIDs such as ibuprofen do not lower body temperature, but they do reduce fever. During endogenous pyrogenic fever (IL-1), it is released from leukocytes and causes an increase in PGs in the brain, which are pyrogen, and by acting on the hypothalamus, they cause an increase in body temperature. Ibuprofen prevents the effect of raising the temperature by (IL-1) by inhibiting the production of thromboxane A2 in the platelets.

Ibuprofen is an anti-inflammatory and antipyretic analgesic and is effective in relieving toothache, headache, arthritis, osteoarthritis, acute gout arthritis and menstrual cramps in women (dysmenorrhea) and other types of pain of moderate intensity. The onset of its effect is 30 to 60 minutes, and the duration of its effect is between 4 and 8 hours, depending on the patient's weight and the dose of the drug. It is recommended to use of fast-release drug forms of this drug for pain relief, especially in cases where anti-inflammatory action is also required (after dental surgery, obstetric or uretopadic surgery, and for the relief of musculoskeletal pain related to soft tissue injuries in athletes such as joint sprains, ligament tears, and stretches) because their onset of effects is faster than delayed release dosage forms.

In terms of the division of drug use, it is in group B in the first six months of pregnancy and in group D in the third trimester.

In lactating women, it is best to take it with a doctor's prescription.

1. Ibuprofen can reduce the antihypertensive effect of ACE inhibitor drugs (such as captopril and enalapril).
2. Ibuprofen can reduce the antihypertensive effect of diuretic drugs.
3. Concomitant use of ibuprofen increases the effect of anticoagulants.
4. Simultaneous use of ibuprofen and anti-diabetic medications. It increases the likelihood of hypoglycemia.
5. Inhibition of renal PGs activity by ibuprofen can increase the plasma concentration of cyclosporine and therefore the risk of nephrotoxicity.
6. Concomitant use of ibuprofen and digoxin increases the blood concentration of the digoxin.
7. Concomitant use of lithium with ibuprofen may increase the blood concentration of lithium (possibly by decreasing the renal clearance of lithium).

Note: To study the interaction of ibuprofen with other drugs, refer to drug interaction books.

1. Ibuprofen should be used with caution in patients with heart failure, hypertension, patients with kidney and liver failure, history of gastrointestinal diseases, bleeding, and ulcers.
2. Ibuprofen should be used with caution in patients treated with anticoagulants such as warfarin, as it increases the risk of internal bleeding if taken at the same time.
3. Older people are more susceptible to side effects.
4. In patients with Aspirin triad (bronchial asthma, aspirin intolerance, rhinitis) with ibuprofen (like any NSAID), fatal asthmatic and anaphylactic reactions have occurred.
5. In case of excessive doses, it can cause central effects such as psychological shock, irritation, and hallucinations.
6. Ibuprofen should not be taken more than 3,200 mg per day.
7. One day before the surgery, the use of the drug should be stopped by dental procedures.
8. It should be taken with food or with antacids.

It includes edema, hypertension, dizziness, nausea, vomiting, burning behind the sternum and ulceration and bleeding in the gastrointestinal tract, which occurs in only a few percent of patients.

1. Children:

• In children 6 months to 12 years old, as a fever reliever, 10 mg/kg/dose every 6 to 8 hours.
• In rheumatoid arthritis, children take 30-50 mg/kg/24h at an 8-hour divided dose (max. 40 mg/kg/dose).
• 10-4 mg/kg/dose every 6 to 8 hours as an analgesic.
• In children over 12 years of age, 200 mg every 4 to 6 hours, up to 1200 mg every 24 hours)

2. Adults:

• The dose of ibuprofen as an anti-inflammatory in adults is 400-800 mg/dose three or four times a day (maximum 3.2 g/day).
• For pain relief, fever relief and dysmenorrhea treatment: 400-200 mg/dose every 4 to 6 hours (max. 1/2 g/day)

Store below 30°C and protect from moisture and freezing.