Cephalosporins bind to PBPS on the bacterial cell membrane to inhibit cell wall construction by a mechanism similar to penicillins.
سفالوسپورین ها به PBPS روی غشای سلولی باکتری متصل می شوند تا با مکانیسمی مشابه پنی سیلین ها ساخت دیواره سلولی را مهار کنند.
This drug is one of the third generation cephalosporins, which has the ability to penetrate the blood-brain barrier and has good activity against penicillin-resistant pneumococci, and drugs of this subgroup are usually considered for the treatment of serious infections.
Pregnancy: Although no studies have been conducted on pregnant women and no side effects have been proven for humans, therefore, the benefits of the drug should be weighed against its harmfulness.
Breastfeeding: This drug is secreted in small amounts in milk. So if necessary. Administration of this drug in lactating women should be done with necessary precautions.
بارداری: اگرچه هیچ مطالعه ای بر روی زنان باردار انجام نشده و عوارض جانبی آن برای انسان اثبات نشده است، بنابراین باید فواید دارو را با مضرات آن سنجید.
Consult your doctor before taking this medicine in the following cases:
In case of history of allergy to any penicillin, cephalosporin; Penicillin-like drugs, penicillamine or other substances such as foods, preservatives and dyes.
In case of kidney diseases, stomach and intestinal diseases.
If taking any type of medicine.
In parallel with the desired therapeutic effect, any drug may cause some unwanted side effects.
Although all these complications are not seen in one person. But consult your doctor if any of the following side effects occur:
Black stool, chest pain, Cold and cough, fever, painful urination, sore throat, abnormal fatigue and weakness, abdominal pain and cramps, diarrhea, Itchy hives, red skin rash, fainting, joint pain, nausea and vomiting, short and irregular breathing, headache and sore throat and tongue.
Poisoning:
If you consume more than the recommended amount, inform your doctor.
The dosage of each drug is determined by the doctor. But the usual dose of this drug is as follows:
Adults and children weighing more than 50 kg: 1-2 grams every 4-12 hours Intramuscular or intravenous.
Maximum intake for adults: 12 grams per day.
Infants and children weighing up to 50 kg: 8.3 -30 mg per kg of body weight every 4 hours or 12.5-45 mg per kg of body weight every 6 hours by intramuscular or intravenous injection.
Infants one to four weeks old: 50 mg per kilogram of body weight every 8 hours intravenously.
Infants up to one week: 50 mg per kilogram of body weight every 12 hours intravenously.
Cephotax® 500:
2 and 10 ml of injectable sterile water for intramuscular injection, respectively Add a vein and shake well. This solution is stable up to 12 hours at room temperature and 24 hours in the refrigerator.
Cephotax® 1:
Add 3 and 10 ml of injectable sterile water for intramuscular and intravenous injection, respectively, and shake well. This solution is stable up to 12 hours at room temperature and 24 hours in the refrigerator.
Since the primary factor in the stability of sodium Cefotaxime pH is soluble, sodium Cefotaxime is stable in aqueous solutions at pH, 5-7 and 4.3 -6.2. It is recommended that Cefotaxime sodium should not be diluted in solutions with a pH of 7.5. Intravenous solutions should be injected within 3-5 minutes.
After the powder is completely dissolved, avoid injection if foreign particles are observed.
For intravenous infusion, dilute the initial solution with 50-100 ml of injectable 0.9% sodium chloride or 5% injectable dextrose 5%. The solution is stable for 24 hours at room temperature.
The color of the solution ranges from pale yellow to amber methfir. Otherwise, avoid the injection.
The amount of sodium is about 2.2 mEq per gram.