nasal spray

Desmopressin is used for the treatment of neurogenic diabetes mellitus, primary nocturnal enuresis (with normal urine concentration), transient hyperuria with trauma or surgery in the pituitary region, von Willebrand disease type I, mild hemophilia type A and thrombocytopenia.

Spray

• Desmopressin is not prescribed in the treatment of nephrogenic insipid diabetes.
• Desmopressin is not prescribed in patients with a concentration of factor VIII of 5% or less.
• Desmopressin is not prescribed in the treatment of severe classic von Willebrand disease.
• Administration of desmopressin in patients with von Willebrand disease type II can cause platelet adhesion and thrombocytopenia, so its use is not recommended in this case.

Clinical use of desmopressin in pregnant women has shown that the drug has no adverse effects on the fetus. Controlled studies on humans have not been performed. Given that animal studies are not always predictive of the drug's effect on humans. This medicine should be used during pregnancy only if there is a definite need. Desmopressin after taking 10 micrograms intranasally, like many drugs, is excreted in breast milk in a very small amount. Therefore, caution should be taken when using it in lactating women.

• Excessive fluid intake (over hydration) should be avoided, especially when desmopressin is given for a homeostatic effect.
• Taking medications that release antidiuretic hormone at the same time (ADH) (e.g. working with mazepine, chlorpropamide, clofibrate)
• It can exacerbate the effect of desmopressin.
• Concomitant administration of demclocycline and lithium may reduce the antidiuretic effect of desmopressin.
• If there is an allergy to desmopressin acetate or inactive components in the product (e.g., benzalkonium chloride), the drug should be avoided.
• Desmopressin if creatinine clearance is less than 50 ml/min. should not be consumed.

• In a small number of patients there may be headaches, nausea, stomach and abdominal pain. Nosebleeds, nasal congestion, rhinitis, and redness of the skin may occur. Sometimes, allergic reactions are caused by an allergy to the preservative in the product (benzalkonium).
• If there is no restriction on the water intake of patients while taking the medicine, it can cause water retention, which is accompanied by a set of symptoms such as low sodium in the blood, weight gain, and in severe cases, convulsions.

Dosage of nasal desmopressin in adults:

For the treatment of central insipid diabetes, take 10 to 40 micrograms (1 to 4 puffs) in one day or in two or three divided doses.

Dosage of nasal desmopressin in children:

• For the treatment of central diabetes mellitus in children up to 3 months. No doses have been suggested yet.
• For children aged 3 months to 12 years. 5 to 30 micrograms are given daily in single doses or in two divided doses. Since the nasal spray does not provide less than 0 to 1 micrograms, the Rhinal Tube Delivery system should be used in patients who require doses of less than 10 micrograms.

Dosage of nasal desmopressin in the elderly:

In the elderly, treatment with this drug should be started with caution and in small doses.

• Desmopressin nasal spray should be stored at a temperature below 25 degrees Celsius.
• Prevent the medicine from freezing.
• Avoid taking expired medicines.
• Keep the medicine out of the reach of children.
• Store the bottle in an upright position.